The lab generates its first batch of human cerebellar organoids, in collaboration with Dr. Liliana Attisano's Applied Organoid core. The organoid contains BARHL1+ neurons which mark the rhombic lip progenitor niche which, when dysregulated, are hypothesized to give rise to forms of medulloblastoma.
PhD candidate Xinghan Sun presents his thesis work on non-coding mutations in Group 3 and 4 medulloblastoma, at the 2024 UofT Medical Biophysics Symposium in Toronto.
PhD candidate Jaskirat Singh Sandhu presents his thesis work on small molecule screens in recurrent glioblastoma at the 2024 UofT Medical Biophysics symposium. May 1 2024.
McMaster University co-op trainee Ellen Mak presents her work optimizing CRISPRi in pediatric brain cancer cell lines at the 2024 OICR Translational Research Conference in King City, ON.
Lab trip to Canada's Wonderland, Summer 2024.
Laser-capture microdissection of developing human hindbrain with Alexandria Albano of OICR Tissue Portal
Laser-capture microdissection of developing human hindbrain with Alexandria Albano of OICR Tissue Portal
Imaging medulloblastoma cells after CRISPRi knockdown.
McMaster University co-op trainee Hana Hajari maintains pediatric brain cancer cells engineered for CRISPRi genetic perturbation.
Ian Cheong presents his single-cell genomics work on developmental origins of medulloblastoma
Celebrating our first CRISPRi knockdown!
Talking epigenomics of childhood brain cancer at the 2023 Canadian Cancer Research Conference in Halifax
Escaping 2023.
Developing hindbrain showing actively dividing cells. The cells of origin of medulloblastoma are towards the bottom of the section.
Shraddha with a cohort of new PIs at the CIHR New PI meeting in Halifax.
University of Waterloo co-op student Alex Chan tries his hand at laser-capture microdissection